Integrative Molecular Analyses of an Individual Transcription Factor-Based Genomic Model for Lung Cancer Prognosis

Figure 1

Identification of lung cancer-specific TFs utilizing mRNA expression profiling from TCGA cohort. (a) Volcano plots display lung cancer-specific TFs through comparison of differential TFs between lung cancer and normal specimens in accordance with and adjusted thresholds. Red dots are indicative of upregulated TFs, while green dots are indicative of downregulated TFs. -axis represents log2 FC while -axis represents -log10 (adjusted ). (b) Hierarchical clustering analyses show the deregulated expression patterns of lung cancer-specific TFs in lung cancer (T) and normal (N) specimens. -axis represents each sample while -axis represents the RNA expression of TFs.

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