Integrative Molecular Analyses of an Individual Transcription Factor-Based Genomic Model for Lung Cancer Prognosis

Table 3

KEGG pathway enrichment results enriched by downstream targets of three TFs.

Description	Gene ratio	BgRatio	value	FDR	value	Count
Circadian rhythm	10/126	31/8101	1.94-11	4.71-09	3.93-09	10
Allograft rejection	5/126	38/8101	0.00028	0.033838	0.028259	5
Oxytocin signaling pathway	9/126	154/8101	0.000636	0.038062	0.031787	9
Phosphatidylinositol signaling system	7/126	97/8101	0.000751	0.038062	0.031787	7
Transcriptional misregulation in cancer	10/126	192/8101	0.000786	0.038062	0.031787	10
FoxO signaling pathway	8/126	131/8101	0.000959	0.038685	0.032308	8
Neurotrophin signaling pathway	7/126	119/8101	0.002472	0.065225	0.054472	7
Longevity regulating pathway	6/126	89/8101	0.002547	0.065225	0.054472	6
Longevity regulating pathway—multiple species	5/126	62/8101	0.002679	0.065225	0.054472	5
Hypertrophic cardiomyopathy	6/126	90/8101	0.002695	0.065225	0.054472	6
Non-small cell lung cancer	5/126	72/8101	0.005121	0.095997	0.080171	5
Inositol phosphate metabolism	5/126	73/8101	0.005431	0.095997	0.080171	5
T cell receptor signaling pathway	6/126	104/8101	0.00551	0.095997	0.080171	6
Fluid shear stress and atherosclerosis	7/126	139/8101	0.005836	0.095997	0.080171	7
MAPK signaling pathway	11/126	294/8101	0.00595	0.095997	0.080171	11
Insulin resistance	6/126	108/8101	0.006608	0.099953	0.083476	6
AMPK signaling pathway	6/126	120/8101	0.010857	0.154556	0.129077	6
Asthma	3/126	31/8101	0.012022	0.157127	0.131224	3
PD-L1 expression and PD-1 checkpoint pathway in cancer	5/126	89/8101	0.012336	0.157127	0.131224	5
GnRH signaling pathway	5/126	93/8101	0.01471	0.164644	0.137502	5
Rap1 signaling pathway	8/126	210/8101	0.016473	0.164644	0.137502	8
Circadian entrainment	5/126	97/8101	0.017373	0.164644	0.137502	5
Inflammatory mediator regulation of TRP channels	5/126	98/8101	0.018086	0.164644	0.137502	5
Inflammatory bowel disease	4/126	65/8101	0.018212	0.164644	0.137502	4
Lipid and atherosclerosis	8/126	215/8101	0.018715	0.164644	0.137502	8
Apoptosis	6/126	136/8101	0.019138	0.164644	0.137502	6
African trypanosomiasis	3/126	37/8101	0.019429	0.164644	0.137502	3
Insulin signaling pathway	6/126	137/8101	0.019767	0.164644	0.137502	6
Yersinia infection	6/126	137/8101	0.019767	0.164644	0.137502	6
Estrogen signaling pathway	6/126	138/8101	0.02041	0.164644	0.137502	6