Role of Annexin A1 in Squamous Cell Lung Cancer Progression
Effect of ANXA1 expression on cellular migration in SQCLC. (a) Representative microscopic images captured of LK2, Lk2-KO, LK2-ANXA1, and Lk2-empty vector at 0 and 48 hours; H1703, H1703-KO, H1703-empty, and H1703-ANXA1 at 0 and 144 hours; and H520-ANXA1 and H520-empty vector at 0 and 9 days from produced wounds. (b and c) Time needed for wound healing in ANXA1 wild type, knockout, and knockout rescued by overexpressing ANXA1 in LK2 and H1703 SQCLC cell lines. (f) Healing of scratch in H520 cells transfected with an empty vector compared to ANXA1 overexpressing vector. ,, and . Migration of cells was analyzed using ImageJ software. All experiments were held with three independent replicates.
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