Role of Annexin A1 in Squamous Cell Lung Cancer Progression

<div>Effect of ANXA1 expression on cellular migration in SQCLC. (a) Representative microscopic images captured of LK2, Lk2-KO, LK2-ANXA1, and Lk2-empty vector at 0 and 48 hours; H1703, H1703-KO, H1703-empty, and H1703-ANXA1 at 0 and 144 hours; and H520-ANXA1 and H520-empty vector at 0 and 9 days from produced wounds. (b and c) Time needed for wound healing in ANXA1 wild type, knockout, and knockout rescued by overexpressing ANXA1 in LK2 and H1703 SQCLC cell lines. 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602Z"></path></g><g transform="matrix(.013,0,0,-0.013,61.296,0)"><path d="M113 -12C146 -12 170 11 170 46C170 78 146 103 114 103S58 78 58 46C58 11 82 -12 113 -12Z"></path></g><g transform="matrix(.013,0,0,-0.013,64.26,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,70.5,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,76.74,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>.</span> Migration of cells was analyzed using ImageJ software. All experiments were held with three independent replicates.</div>

Disease Markers

Role of Annexin A1 in Squamous Cell Lung Cancer Progression

Figure 3