Association of Red Blood Cell Distribution Width Levels with Connective Tissue Disease-Associated Interstitial Lung Disease (CTD-ILD)

Table 2

Univariate and multivariate Cox proportional regression analysis of the relationships between clinical and biochemical parameters and prognosis of CTD-ILD patients.

Variables	Univariate cox model			Multivariate cox model
	HR	95.0% CI	value	HR	95.0% CI	value
Age (years)	1.04	1.014-1.066	0.003	1.022	0.985-1.061	0.243
Gender (female)	0.569	0.329-0.984	0.044	0.330	0.122-0.892	0.029
Smoking history	0.564	0.296-1.075	0.082	2.130	0.599-7.576	0.243
sPAP (mmHg)	1.052	1.013-1.092	0.008	1.017	0.974-1.062	0.450
ESR (mm/h)	1.015	1.006-1.024	0.002	1.009	0.989-1.029	0.383
CPR (mg/L)	1.008	0.997-1.019	0.164	0.993	0.973-1.014	0.508
WBC count (10^9/l)	1.175	1.060-1.302	0.002	1.065	0.904-1.256	0.451
RDW (%)	4.251	3.145-5.745	<0.001	1.495	1.210-1.846	<0.001
LDH (U/L)	1.002	1.000-1.004	0.015	0.998	0.992-1.003	0.448
CEA (ng/ml)	1.065	1.023-1.109	0.002	1.029	0.969-1.092	0.349
CYFRA21-1(ng/ml)	1.135	1.032-1.249	0.009	1.044	0.879-1.239	0.625
NSE (ng/ml)	0.985	0.929-1.044	0.602	0.942	0.850-1.045	0.263
PaO2/FiO2 ratio (mmHg)	0.996	0.992-1.001	0.119	0.996	0.989-1.003	0.256

sPAP: systolic pulmonary arterial pressure; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; WBC: white blood cell; RDW: red blood cell distribution width; LDH: lactate dehydrogenase; NSE: neuron-specific enolase; CYFRA21-1: cytokeratin 21-1; CEA: carcinoembryonic antigen; PaO2/FiO2: oxygenation index.