Identification of Novel Biomarkers for Evaluating Disease Severity in House-Dust-Mite-Induced Allergic Rhinitis by Serum Metabolomics

Table 2

Top ten metabolites with different variations discriminating MAR patients from health controls.

Metabolites	Ion mode	VIP	value	Regulation	AUC	Pathway
Sarcosine	Positive	3.24	0.005	Up	0.77	Arginine and proline metabolism
Palmitic acid	Positive	2.74	0.000	Up	0.87	Fatty acid metabolism
5-Methylthioadenosine	Positive	2.58	0.002	Up	0.60	Cysteine and methionine metabolism
Triethanolamine	Negative	2.16	0.047	Up	0.79	Glycerophospholipid metabolism
5-Methoxyindoleacetate	Negative	1.86	0.004	Up	0.75	Tryptophan metabolism
trans-Vaccenic acid	Positive	1.79	0.004	Down	0.93	Fatty acid metabolism
Creatinine	Negative	1.73	0.000	Up	0.78	Arginine and proline metabolism
S1P	Negative	1.70	0.019	Up	0.91	Sphingolipid metabolism
Arachidic acid	Positive	1.62	0.014	Down	0.54	Fatty acid metabolism
L-Methionine	Negative	1.61	0.022	Down	0.49	Cysteine and methionine metabolism

MAR: mild allergic rhinitis; VIP: variable importance for project; AUC: area under the curve; S1P: sphingosine-1-phosphate.