Identification of Novel Biomarkers for Evaluating Disease Severity in House-Dust-Mite-Induced Allergic Rhinitis by Serum Metabolomics

Table 3

Top ten metabolites with different variations discriminating MSAR patients from health controls.

Metabolites	Ion mode	VIP	value	Regulation	AUC	Pathway
S1P	Positive	1.97	0.005	Up	0.89	Sphingolipid metabolism
2-Oxoadipic acid	Negative	2.36	0.002	Up	0.68	Tryptophan metabolism
Phosphorylcholine	Negative	2.19	0.002	Up	0.86	Glycerophospholipid metabolism
Cytidine	Negative	2.01	0.000	Up	0.83	Pyrimidine metabolism
Betaine	Positive	1.97	0.000	Up	0.84	Glycine, serine and threonine metabolism
Sarcosine	Negative	1.95	0.002	Up	0.92	Arginine and proline metabolism
1,3-Diaminopropane	Positive	1.85	0.007	Up	0.61	Beta-alanine metabolism
Taurocholic acid	Positive	1.82	0.006	Down	0.74	Taurine and hypotaurine metabolism
Linoleic acid	Negative	1.78	0.026	Down	0.79	Fatty acid metabolism
cis-9-Palmitoleic acid	Positive	1.75	0.005	Up	0.64	Fatty acid metabolism

MSAR: moderate-severe allergic rhinitis; VIP: variable importance for project; AUC: area under the curve; S1P: sphingosine-1-phosphate.