Identification of Novel Biomarkers for Evaluating Disease Severity in House-Dust-Mite-Induced Allergic Rhinitis by Serum Metabolomics
Table 4
Top ten metabolites with different variations discriminating MSAR from MAR.
Metabolites
Ion mode
VIP
value
Regulation
AUC
Pathway
Linoleic acid
Positive
2.79
0.049
Down
0.77
Fatty acid metabolism
Betaine
Positive
2.24
0.034
Up
0.60
Glycine, serine, and threonine metabolism
Coumarin
Positive
2.11
0.012
Down
0.63
Phenylpropanoid biosynthesis
S1P
Negative
2.06
0.009
Up
0.72
Sphingolipid metabolism
Palmitoleic acid
Positive
1.97
0.016
Down
0.75
Fatty acid metabolism
trans-Vaccenic acid
Positive
1.89
0.003
Down
0.65
Fatty acid metabolism
D-Glucurono-6,3-lactone
Negative
1.88
0.000
Up
0.59
Ascorbate and aldarate metabolism
Sarcosine
Negative
1.83
0.007
Up
0.91
Arginine and proline metabolism
Cytidine
Positive
1.79
0.017
Up
0.74
Pyrimidine metabolism
Pyroglutamic acid
Negative
1.72
0.014
Down
0.81
Glutathione metabolism
MAR: mild allergic rhinitis; MSAR: moderate-severe allergic rhinitis; VIP: variable importance for project; AUC: area under the curve; S1P: sphingosine-1-phosphate.
