Association of Polymorphisms in Vitamin D-Metabolizing Enzymes DHCR7 and CYP2R1 with Cancer Susceptibility: A Systematic Review and Meta-Analysis

Table 1

Characteristics of eligible studies.

No.	First author	Year	Ethnicity	Sample size		Source of control groups	Genotyping method	Adjusted factors	Citation
				Case	Control
1	Isabel S. Carvalho	2019	Caucasian (Portugal)	500	500	PB	PCR-RFLP	Age, sex	[12]
2	Prajjalendra Barooah	2019	Caucasian (Indian)	60	102	HB	PCR-RFLP	Age, sex	[13]
3	Jianzhou Yang	2017	Asian (China)	565	557	PB	GenomeLab SNPstream	Age, sex	[35]
4	Alison M. Mondul	2015	Caucasian (European)	8618	9960	HB	TaqMan or genome-wide scans	Age	[36]
5	Tess V. Clendenen	2015	Caucasian (Swedish)	733	1432	PB	Illumina GoldenGate assay	Age, menopausal status	[37]
6	Fabio Pibiri	2014	African (African-American)	902	760	PB	Sequenom MassARRAY	Age, sex, ancestry	[38]
7	Touraj Mahmoudi	2014	Caucasian (Iranian)	290	354	HB	PCR-RFLP	Age, BMI, sex	[9]
8	Wei Wang	2014	Caucasian (Hispanic)	826	779	PB	Illumina GoldenGate assay	Age, BMI
	Wei Wang	2014	Mixed (non-Hispanic)	224	130	PB	Illumina GoldenGate assay	Age, BMI	[39]
9	Christian M. Lange	2013	Asian (Japanese)	803	1253	HB	Competitive allele-specific TaqMan PCR	Sex	[40]
10	Alison M. Mondul	2013	Caucasian	9378	9986	PB	TaqMan	Age, ethnicity	[41]
11	Laura N. Anderson	2013	Caucasian (Canada)	628	1192	PB	MassARRAY	Age, sex	[11]
12	Marissa Penna-Martinez	2012	Caucasian (Germany)	253	302	PB	TaqMan	NM	[42]

Note: HB: hospital based; PB: population based; PCR-RFLP: in reaction-restriction fragment length polymorphism; NM: not mentioned.