Association of Polymorphisms in Vitamin D-Metabolizing Enzymes DHCR7 and CYP2R1 with Cancer Susceptibility: A Systematic Review and Meta-Analysis

Table 2

Genotype frequency distributions of lncRNA SNPs studied in included studies.

First author	Year	Gene	SNPs^a	Type of cancer	Ethnicity	Sample size		Case			Control			Quality score		Included in meta-analysis
						Case	Control	Homozygote wild	Heterozygote	Homozygote variant	Homozygote wild	Heterozygote	Homozygote variant
Isabel S. Carvalho	2019	CYP2R1	rs2060793 (G/A)	TC	Caucasian (Portugal)	500	500	189	236	75	183	256	61	7	0.047	No^c
	2019	DHCR7	rs12785878 (T/G)	TC	Caucasian (Portugal)	500	500	150	251	99	197	234	69	7	0.971	Yes
Prajjalendra Barooah	2019	CYP2R1	rs10741657 (G/A)	HCC	Caucasian (Indian)	60	102	28	23	9	51	35	16	4.5	0.025	No^c
Jianzhou Yang	2017	DHCR7	rs3829251 (G/A)	ESCC	Asian (China)	565	557	302	218	45	283	232	42	8	0.557	No^b
Alison M. Mondul	2015	CYP2R1	rs10741657 (G/A)	BC	Caucasian (European)	8618	9960	3276	4041	1301	3708	4766	1486	6.5	0.475	Yes
	2015	DHCR7	rs12785878 (T/G)	BC	Caucasian (European)	9224	10560	4935	3620	669	5674	4052	834	5.5	0.003	No^c
Tess V. Clendenen	2015	CYP2R1	rs10741657 (G/A)	BC	Caucasian (Swedish)	733	1432	200	358	175	405	720	307	7.5	0.696	Yes
	2015	DHCR7	rs12785878 (T/G)	BC	Caucasian (Swedish)	733	1433	273	371	89	571	659	203	7.5	0.562	Yes
	2015	DHCR7	rs1790349 (A/G)	BC	Caucasian (Swedish)	732	1431	348	326	58	752	571	108	7.5	0.978	Yes
Fabio Pibiri	2014	CYP2R1	rs12794714 (G/A)	CRC	African (African-American)	902	760	638	253	11	501	239	20	9.5	0.175	Yes
Touraj Mahmoudi	2014	CYP2R1	rs12794714 (G/A)	CRC	Caucasian (Iranian)	290	354	93	135	62	110	167	77	7	0.364	Yes
Wei Wang	2014	CYP2R1	rs2060793 (G/A)	BC	Mixed (Hispanic)	826	779	303	391	132	315	356	108	9.5	0.644	Yes
	2014	CYP2R1	rs2060793 (G/A)		Caucasian (non-Hispanic)	224	130	89	104	31	51	58	21	8.5	0.512	Yes
	2014	DHCR7	rs12785878 (T/G)	BC	Mixed (Hispanic)	826	779	189	410	227	185	353	241	7.5	0.013	No^c
	2014	DHCR7	rs12785878 (T/G)	BC	Caucasian (non-Hispanic)	224	130	123	90	11	62	55	13	8.5	0.876	Yes
	2014	DHCR7	rs1790349 (A/G)	BC	Mixed (Hispanic)	826	779	573	227	26	527	227	25	8.5	0.927	Yes
	2014	DHCR7	rs1790349 (A/G)	BC	Caucasian (non-Hispanic)	224	130	168	52	4	95	30	5	8.5	0.195	Yes
Christian M. Lange	2013	CYP2R1	rs10741657 (G/A)	HCC	Asian (Japanese)	803	1253	320	377	106	482	597	174	8.5	0.615	Yes
	2013	DHCR7	rs12785878 (T/G)	HCC	Asian (Japanese)	803	1253	84	336	383	153	543	557	8.5	0.247	Yes
	2013	DHCR7	rs12785878 (T/G)	HCC	Caucasian (German)	116	208	63	44	9	113	77	18	8.5	0.353	Yes
Alison M. Mondul	2013	CYP2R1	rs10741657 (G/A)	PC^1	Caucasian	9378	9986	3481	4392	1505	3789	4667	1530	9	0.137	Yes
	2013	DHCR7	rs12785878 (T/G)	PC^1	Caucasian	9620	10225	4979	3816	825	5221	4047	957	8		No^c
Laura N. Anderson	2013	CYP2R1	rs10741657 (G/A)	PC^2	Caucasian (Canada)	625	1191	262	286	77	451	550	190	8	0.304	Yes
	2013	CYP2R1	rs12794714 (G/A)	PC^2	Caucasian (Canada)	628	1192	180	307	141	399	559	234	8	0.131	Yes
Marissa Penna-Martinez	2012	CYP2R1	rs10741657 (G/A)	TC	Caucasian (German)	253	302	96	110	47	119	139	44	7.5	0.742	Yes
	2012	CYP2R1	rs12794714 (G/A)	TC	Caucasian (German)	253	302	78	130	45	94	144	64	7.5	0.522	Yes

Note: : the value for Hardy-Weinberg equilibrium in control groups; ^amajor/minor; ^bexcluded due to the limited number for this locus; ^cexcluded due to the SNP not being in accordance with HWE. The results are in bold if ; TC = thyroid cancer; HCC = hepatocellular carcinoma; ESCC = esophageal squamous cell carcinoma; BC = breast cancer; PC¹ = prostate cancer; PC² = pancreas cancer.