Research Article
Cancer-Associated Fibroblasts Regulate Bladder Cancer Invasion and Metabolic Phenotypes through Autophagy
Figure 4
Autophagy in CAFs affects aerobic glycolysis and MMP-9 expression in T24 cells in vitro: (a) compared with the control group, the lactate levels in the cell medium increased in both siAtg5-treated and rapamycin-treated groups (); (b, c) Western blot analyses of MMP-9 and several key glycolytic genes, including HK2, SLC2A1, MCT1, and MCT4 in T24 cells: the expression levels of these genes increased obviously in the autophagy-enhanced group.
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