Diagnostic Accuracy with Total Adenosine Deaminase as a Biomarker for Discriminating Pleural Transudates and Exudates in a Population-Based Cohort Study

Table 4

Calibration with internal validation by bootstrapping of the 95% confidence interval of the area under the ROC curve after 1000 resamples for the classification of pleural exudate and transudate with total adenosine deaminase.

Development AUC		Internal validation for optimism-correct AUC (95% CI)	Variation	Chi-squared test
95% CI	Observed	Expected	%	value
Minimum	0.751	0.736	-1.99	0.092 ()
Maximum	0.877	0.883	+ 0.68	0.027 ()

A tolerance 2% with 1000 replications was considered appropriate. Abbreviations: 95% CI: 95% confidence Interval; AUC: area under the ROC curve.