Diagnostic Value of Circulating Progranulin and Its Receptor EphA2 in Predicting the Atheroma Burden in Patients with Coronary Artery Disease

Table 3

Univariate and multivariate logistic regression of risk factors of ACS.

Variable	Univariate			Multivariate
	OR	95% CI	value	OR	95% CI	value
Males, (%)	0.469	0.233~0.941	0.033	8.523	1.422~51.091	0.019
Age (y) ()	1.018	0.989~1.047	0.235
BMI (kg/m^2)	0.959	0.868~1.059	0.408
Hypertension, (%)	1.074	0.604~1.910	0.809
Diabetes mellitus, (%)	0.673	0.377~1.204	0.182
Smoking, (%)	1.023	0.578~1.810	0.938
eGFR (mL/min/1.73 m^2)	0.985	0.968~1.002	0.081
Total cholesterol (mg/dL)	1.015	1.007~1.023	<0.001	0.972	0.943~1.001	0.058
LDL (mg/dL)	1.024	1.014~1.033	<0.001	1.050	1.014~1.087	0.006
Hemoglobin A1c (%)	1.511	1.162~1.963	0.002
NT-proBNP (pg/mL)	1.002	1.001~1.003	<0.001	1.003	1.001~1.005	0.006
cTnT (ng/mL)			<0.001
CK-MB (U/L)	1.080	1.037~1.125	<0.001
hs-CRP (mg/L)	1.117	1.060~1.176	<0.001
PGRN (ng/mL)	1.022	1.001~1.044	0.039
EphA2 (pg/mL)	11.289	5.722~22.274	<0.001	10.715	3.259~35.227	<0.001
LVEF (%)	0.871	0.828~0.917	<0.001
Gensini score	1.039	1.027~1.051	<0.001	1.031	1.014~1.048	<0.001

Forward Wald method was used in the multivariate logistic analysis. ACS: acute coronary syndrome; OR: relative risk; CI: confidence interval; BMI: body mass index; eGFR: estimated glomerular filtration rate; LDL: low-density lipoprotein; NT-proBNP: N-terminal pro B-type natriuretic peptide; cTnT: cardiac troponin T; CK-MB: creatine kinase MB; hs-CRP: hypersensitive C-reactive protein; PGRN: progranulin; EphA2: Eph-receptor tyrosine kinase-type A2; LVEF: left ventricular ejection fraction. EphA2 was divided into <116.32 pg/mL and ≥ 116.32 pg/mL according to the median.