Diagnostic Value of Circulating Progranulin and Its Receptor EphA2 in Predicting the Atheroma Burden in Patients with Coronary Artery Disease
Table 4
Differences between the lower and greater atheroma burden.
Parameter
()
()
value
Non-CTO ()
CTO ()
value
Males, (%)
60 (75.0)
62 (78.5)
0.708
83 (73.4)
39 (84.8)
0.150
Age (y) ()
0.510
0.764
BMI (kg/m2)
0.469
0.524
Hypertension, (%)
55 (68.7)
45 (57.0)
0.141
69 (61.1)
31 (67.4)
0.476
Diabetes mellitus, (%)
27 (33.7)
36 (45.6)
0.146
42 (37.2)
21 (45.6)
0.373
Smoking, (%)
36 (45.0)
32 (40.5)
0.632
46 (40.7)
22 (47.8)
0.480
eGFR (mL/min/1.73m2)
83.0 (71.0, 91.0)
83.0 (71.0, 92.0)
0.710
85.0 (71.0, 91.0)
83.0 (71.0, 95.0)
0.188
Total cholesterol (mg/dL)
124.1 (107.1, 160.6)
145.4 (128.3, 181.9)
0.002
133.0 (106.9, 164.3)
152.7 (126.8, 214.6)
0.021
LDL (mg/dL)
55.3 (38.1, 93.6)
82.7 (62.8, 110.0)
<0.001
57.6 (39.8, 96.1)
84.1 (63.8, 124.9)
0.003
Hemoglobin A1c (%)
6.1 (5.6, 6.9)
6.6 (5.6, 7.7)
0.180
6.2 (5.6, 7.1)
6.4 (5.6, 7.7)
0.538
NT-proBNP (pg/mL)
119.7 (46.3, 311.7)
393.0 (132.0, 1089.0)
<0.001
140.0 (58.7, 373.6)
381.0 (112.0, 1040.0)
<0.001
cTnT (ng/mL)
0.01 (0.007, 0.045)
0.078 (0.018, 0.713)
<0.001
0.011 (0.008, 0.038)
0.064 (0.015, 0.633)
0.001
CK-MB (U/L)
15.0 (12.0, 18.0)
19.0 (13.0, 40.0)
0.004
14.0 (12.0, 19.0)
21.0 (14.0, 41.0)
0.009
hs-CRP (mg/L)
0.95 (0.45, 4.55)
4.80 (0.90, 14.85)
<0.001
1.00 (0.50, 4.55)
4.85 (0.90, 11.7)
0.003
PGRN (ng/mL)
40.1 (33.5, 50.6)
42.4 (37.4, 50.0)
0.208
39.4 (33.8, 46.7)
44.7 (39.7, 51.0)
0.052
EphA2 (pg/mL)
107.8 (27.0, 273.7)
243.8 (56.1, 368.8)
0.031
45.7 (23.1, 268.2)
298.0 (215.5, 379.2)
<0.001
Data are expressed as or median (interquartile range) or (%).CTO: chronic total occlusion. BMI: body mass index; eGFR: estimated glomerular filtration rate; LDL: low-density lipoprotein; NT-proBNP: N-terminal pro B-type natriuretic peptide; cTnT: cardiac troponin T; CK-MB:, creatine kinase-MB; hs-CRP: high-sensitivity C-reactive protein; PGRN: progranulin; EphA2:, Eph-receptor tyrosine kinase-type A2.
