Diagnostic Value of Circulating Progranulin and Its Receptor EphA2 in Predicting the Atheroma Burden in Patients with Coronary Artery Disease

Table 5

Diagnostic efficiency of circulating EphA2 and PGRN levels to predict CTO.

Parameter	AUC	95% CI	Optimal cutoff	Sensitivity (%)	Specificity (%)	value	Diagnose OR	Accuracy
PGRN (ng/mL)	0.604	0.508, 0.700	38.2	78.3	44.3	0.045	2.83	0.542
EphA2 (pg/mL)	0.686	0.600, 0.772	63.6	89.1	46.3	<0.001	7.23	0.592
Gensini score	0.911	0.864, 0.958	50.5	88.6	81.9	<0.001	38.84	0.845
NT-proBNP (pg/mL)	0.686	0.595, 0.777	209.4	73.9	61.5	<0.001	4.379	0.646
cTnT (ng/mL)	0.673	0.584, 0.763	0.018	71.7	56.9	0.001	3.806	0.608
CK-MB (U/L)	0.626	0.520, 0.731	20.5	54.5	75.2	0.016	3.778	0.699
hs-CRP (mg/L)	0.656	0.559, 0.752	4.65	58.7	70.6	0.003	3.402	0.671

PGRN: progranulin; EphA2: Eph-receptor tyrosine kinase-type A2; NT-proBNP: N-terminal pro B-type natriuretic peptide; cTnT: cardiac troponin T; CK-MB: creatine kinase-MB; hs-CRP: high-sensitivity C-reactive protein; CTO: chronic total occlusion.