A Comparison of GFR Calculated by Cockcroft-Gault vs. MDRD Formula in the Prognostic Assessment of Patients with Acute Pulmonary Embolism
Table 1
General characteristic of all patients and depending on glomerular filtration rate.
All pts.
(ml/min/1.73 m2)
(ml/min/1.73 m2)
value
(ml/min)
(ml/min)
value
Characteristics
Age (years)
71 (18-101)
76 (20-101)
77 (20-94)
0.004
79 (20-101)
83 (20-101)
0.0001
Sex (male/female)
1148 (50.4%)/1126 (49.6%)
238 (31%)/531 (69%)
38 (36%)/68 (64%)
0.002
385 (43%)/515 (57%)
56 (39%)/88 (61%)
0.004
BMI (kg/m2) ()
26.6 [23.8-30.1]
26.6 [24.2-30.1]
26.9 [23.9-30.1]
Non-significant (NS)
25.3 [23.2-28.3]
24.2 [22.5-27.7]
0.01
HR ()
90 [78-105]
88 [76-105]
93 [75-110]
NS
89 [76-103]
92 [76-110]
0.08
SBP ()
130 [115-143]
130 [110-145]
115 [93-140]
0.04
130 [110-144]
119 [100-140]
NS
Creatinine (μmol/l)
86.6 [70.7-106]
120.2 [101.6-145.8]
211.3 [171.5-253.7]
<0.001
107.8 [89.3-138.8]
166.2 [141.4-221]
<0.001
eGFRMDRD (ml/min/1.73 m2)
72.5 [53.3-93]
45.5 [35.5-53.5]
24.7 [19.5-28]
<0.001
50.6 [37.4-63.4]
29.9 [22.5-36.2]
<0.001
eGFRCG (ml/min)
70.1 [48.5-99]
43.1 [33.1-55.5]
24.4 [18.9-33.4]
<0.001
43.6 [34.4-51.9]
24.6 [19.3-27.4]
<0.001
NTproBNP (pmol/l) ()
87.1 [15.9-350.95]
275.5 [75.2-876.6]
583.4 [155.7-2155]
<0.001
300.9 [87.3-1031.5]
642.3 [143.5-1539.3]
<0.001
CHF ()
232 (10%)
131 (17%)
23 (21.6%)
<0.001
156 (17%)
36 (25%)
<0.001
Pulmonary disease ()
221 (9.8%)
92 (12%)
18 (17%)
0.004
105 (11%)
18 (12.5%)
NS
Cancer ()
379 (17%)
129 (16%)
21 (20%)
NS
137 (15%)
21 (14%)
NS
on TTE ()
314 (22%)
118 (15%)
17 (16%)
NS
121 (13.4%)
19 (13%)
NS
Elevated troponin ()
738 (39%)
305 (39%)
55 (52%)
<0.001
326 (36%)
67 (46.5%)
0.002
Short-term outcome
30-day bleeding
135 (6%)
64 (8%)
15 (14%)
0.001
70 (7.7%)
17 (12%)
0.002
30-day all-cause mortality
128 (5.6%)
67 (8.7%)
15 (14%)
<0.001
78 (8.6%)
26 (18%)
<0.001
30-day PE-related mortality
69 (3%)
41 (5.3%)
12 (11%)
<0.001
49 (5.4%)
20 (14%)
<0.001
Long-term outcome
180-day mortality
208 (9%)
94 (12%)
23 (21.6%)
<0.001
107 (12%)
32 (22%)
0.005
BMI: body mass index; CG: Cockcroft-Gault; CHF: chronic heart failure; eGFR: estimated glomerular filtration rate; HR: heart rate; LV: left ventricle; MDRD: Modification of Diet in Renal Disease; NS: nonsignificant; NTproBNP: N-terminal probrain natriuretic peptide; RV: right ventricle; SBP: systolic blood pressure; TTE: transthoracic echocardiogram. Values in square parenthesis represent quartiles from first to third [Q1-Q3] for the nonparametrical parameters.
