Prognostic Significance of the Combined Score of Plasma Fibrinogen and Neutrophil-Lymphocyte Ratio in Patients with Spontaneous Intracerebral Hemorrhage
Table 1
Baseline clinical characteristics of patients with spontaneous ICH in original cohort.
Clinical variables
Total ()
3-month functional outcome
1-month mortality
Poor outcome ()
Good outcome ()
value
Death ()
Survival ()
value
Age (year)
0.557
0.981
Male
299 (69.4)
227 (69.4)
72 (69.2)
0.971
53 (66.3)
246 (70.1)
0.502
GCS
13 (8,15)
12 (7,14)
15 (14,15)
<0.001
8 (6,11)
13 (10,15)
<0.001
Admission SBP (mmHg)
0.117
0.498
Admission DBP (mmHg)
0.723
0.114
Onset to CT (hours)
6 (4,12)
6 (4,10)
7 (4,20)
0.020
5 (4,9)
6 (4,13)
0.262
History of hypertension
245 (56.8)
188 (57.5)
57 (54.8)
0.630
46 (57.5)
199 (56.7)
0.896
History of diabetes mellitus
31 (7.2)
28 (8.6)
3 (2.9)
0.051
3 (3.8)
28 (8.0)
0.187
Smoking
143 (33.2)
117 (35.8)
26 (25.0)
0.042
23 (28.7)
120 (34.2)
0.351
Previous stroke
22 (5.1)
19 (5.8)
3 (2.9)
0.238
2 (2.5)
20 (5.7)
0.373
Antiplatelet or anticoagulation
20 (4.6)
14 (4.3)
6 (5.8)
0.718
5 (6.3)
15 (4.3)
0.643
Hematoma volume (mL)
20.30 (7.81,35.78)
25.16 (9.06,40.42)
9.25 (2.64,21.70)
<0.001
28.69 (10.72,49.69)
17.69 (7.05,32.94)
<0.001
Hematoma location
Supratentorial
358 (83.1)
284 (86.9)
74 (71.2)
<0.001
66 (82.5)
292 (83.2)
0.882
Infratentorial
73 (16.9)
43 (13.1)
30 (28.8)
14 (17.5)
59 (16.8)
Presence of IVH
170 (39.4)
147 (45.0)
23 (22.1)
<0.001
57 (71.3)
113 (32.2)
<0.001
Presence of HE
104 (24.1)
90 (27.5)
14 (13.5)
0.004
25 (31.3)
79 (22.5)
0.099
Treatment
Surgical intervention
114 (26.5)
107 (32.7)
7 (6.7)
<0.001
30 (37.5)
84 (23.9)
0.013
Conservative treatment
317 (73.5)
220 (67.3)
97 (93.3)
50 (62.5)
267 (76.1)
PLT (10ˆ9/L)
151 (115,199)
151 (114,198)
150 (120,205)
0.824
143 (112,199)
151 (116,201)
0.374
PT (s)
11.4 (10.9,12.3)
11.4 (10.9,12.3)
11.6 (10.9,12.3)
0.482
11.8 (10.9,13.0)
11.4 (10.9,12.1)
0.075
APTT (s)
26.5 (23.7,29.7)
26.5 (23.7,29.4)
26.6 (23.8,30.3)
0.811
26.5 (23.5,30.1)
26.6 (23.8,29.5)
0.974
INR
0.99 (0.93-1.06)
0.98 (0.93,1.05)
1.00 (0.94,1.06)
0.153
1.00 (0.93,1.10)
0.98 (0.93,1.04)
0.066
NLR
8.18 (4.81,13.20)
8.77 (5.14,13.88)
6.44 (4.25,10.49)
0.001
12.53 (7.99,19.48)
7.35 (4.32,11.98)
<0.001
Fibrinogen
2.76 (2.29,3.38)
2.92 (2.37,3.54)
2.44 (2.20,2.97)
<0.001
3.34 (2.87,4.47)
2.65 (2.23,3.23)
<0.001
F-NLR score
0
164 (38.1)
102 (31.2)
62 (59.6)
<0.001
7 (8.8)
157 (44.7)
<0.001
1
183 (42.5)
149 (45.6)
34 (32.7)
40 (50.0)
143 (40.7)
2
84 (19.5)
76 (23.2)
8 (7.7)
33 (41.3)
51 (14.5)
Data are expressed as (%), , or median (25th, 75th quartile). Abbreviation: ICH, intracerebral hemorrhage; SD, standard deviation; GCS, Glasgow Coma Scale; SBP, systolic blood pressure; DBP, diastolic blood pressure; IVH, intraventricular hemorrhage; HE, hematoma expansion; PLT, platelet; PT, prothrombin time; APTT, activated partial thromboplastin time; INR, international normalized ratio; F, fibrinogen; NLR, neutrophil to lymphocyte ratio.
