Prognostic Significance of the Combined Score of Plasma Fibrinogen and Neutrophil-Lymphocyte Ratio in Patients with Spontaneous Intracerebral Hemorrhage
Table 2
Baseline clinical characteristics of patients with spontaneous ICH in validation cohort.
Clinical variables
Total ()
3-month functional outcome
1-month mortality
Poor outcome ()
Good outcome ()
value
Death ()
Survival ()
value
Age (year)
0.561
0.584
Male
166(66.1)
113(63.1)
53(73.6)
0.112
23(62.2)
143(66.8)
0.580
GCS
14(10,15)
13(8,15)
15(14,15)
<0.001
8(7,13)
14(12,15)
<0.001
Admission SBP (mmHg)
0.342
0.128
Admission DBP (mmHg)
0.833
0.155
Onset to CT (hours)
6(4,12)
6(4,12)
6(4,17)
0.375
6(3,17)
6(4,12)
0.854
History of hypertension
142(56.6)
104(58.1)
38(52.8)
0.342
18(48.6)
124(57.9)
0.292
History of diabetes mellitus
16(6.4)
14(7.8)
2(2.8)
0.233
0(0.0)
16(7.5)
0.176
Smoking
71(28.3)
54(30.2)
17(23.6)
0.297
6(16.2)
65(30.4)
0.077
Previous stroke
13(5.2)
10(5.6)
3(4.2)
0.885
0(0.0)
13(6.1)
0.255
Antiplatelet or anticoagulation
19(7.6)
11(6.1)
8(11.1)
0.179
4(10.8)
15(7.0)
0.638
Hematoma volume (mL)
18.48(7.80,35.20)
22.80(9.24,36.75)
9.22(2.66,27.27)
<0.001
35.34(20.70,48.78)
15.72(7.01,31.49)
<0.001
Hematoma location
Supratentorial
207(82.5)
159(88.8)
48(66.7)
<0.001
33(89.2)
174(82.2)
0.244
Infratentorial
44(17.5)
20(11.2)
24(33.3)
4(10.8)
40(17.8)
Presence of IVH
91(36.3)
80(44.7)
11(15.3)
<0.001
24(64.9)
67(31.3)
<0.001
Presence of HE
59(23.5)
47(26.3)
12(16.7)
0.105
16(43.2)
43(20.1)
0.002
Treatment
Surgical intervention
49(19.5)
45(25.1)
4(5.6)
<0.001
11(29.7)
38(17.8)
0.090
Conservative treatment
202(80.5)
134(74.9)
68(94.4)
26(70.3)
176(82.2)
PLT (10ˆ9/L)
152(115,204)
152(114,203)
153(116,210)
0.634
127(105,195)
157(120,209)
0.036
PT (s)
11.5(10.9,12.4)
11.4(10.9,12.2)
11.5(10.9,12.5)
0.659
12.4(11.1,13.2)
11.4(10.9,12.1)
0.006
APTT (s)
26.5(23.6,29.3)
26.3(23.6,29.0)
26.7(23.4,29.8)
0.634
27.8(24.8,31.4)
26.3(23.6,29.0)
0.069
INR
0.99(0.93,1.06)
0.98(0.93,1.06)
1.00(0.94,1.08)
0.254
1.05(0.94,1.13)
0.98(0.93,1.05)
0.018
NLR
8.18(4.88,12.72)
8.94(5.38,13.88)
6.45(4.48,9.73)
0.001
16.73(9.05,21.89)
7.27(4.48,10.79)
<0.001
Fibrinogen (g/L)
2.76(2.37,3.34)
2.98(2.43,3.51)
2.50(2.25,2.87)
<0.001
3.54(3.04,4.82)
2.65(2.32,3.22)
<0.001
F-NLR score
0
111(44.2)
64(35.8)
47(65.3)
<0.001
1(2.7)
110(51.4)
<0.001
1
87(34.7)
62(34.6)
25(34.7)
15(40.5)
72(33.6)
2
53(21.1)
53(29.6)
0(0.0)
21(56.8)
32(15.0)
Data are expressed as (%), , or median (25th, 75th quartile). Abbreviation: ICH, intracerebral hemorrhage; SD, standard deviation; GCS, Glasgow Coma Scale; SBP, systolic blood pressure; DBP, diastolic blood pressure; IVH, intraventricular hemorrhage; HE, hematoma expansion; PLT, platelet; PT, prothrombin time; APTT, activated partial thromboplastin time; INR, international normalized ratio; F, fibrinogen; NLR, neutrophil to lymphocyte ratio.
