H19 Overexpression Improved Efficacy of Mesenchymal Stem Cells in Ulcerative Colitis by Modulating the miR-141/ICAM-1 and miR-139/CXCR4 Axes

Figure 2

RNA and protein levels of miR-141, miR-139, ICAM-1, and CXCR4 in MSC was regulated by the transfection of H19 ( value <0.05 vs. pcDNA). (a) RNA level of H19 was boosted in MSC transfected with H19. (b) RNA level of miR-141 was decreased in MSC transfected with H19. (c) mRNA level of ICAM-1 was increased in MSC transfected with H19. (d) RNA level of miR-139 was decreased in MSC transfected with H19. (e) mRNA level of CXCR4 was increased in MSC transfected with H19. (f) protein level of ICAM-1 was higher in MSC transfected with H19. (g) Protein level of CXCR4 was higher in MSC transfected with H19.

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