H19 Overexpression Improved Efficacy of Mesenchymal Stem Cells in Ulcerative Colitis by Modulating the miR-141/ICAM-1 and miR-139/CXCR4 Axes

Figure 3

RNA and protein levels of miR-141, miR-139, ICAM-1, and CXCR4 in MSC transfected with scramble control or H19 siRNA ( value <0.05 vs. control). (a) RNA level of H19 was reduced by the transfection of H19 siRNA in MSC. (b) RNA level of miR-141 was promoted by the transfection of H19 siRNA in MSC. (c) mRNA level of ICAM-1 was inhibited by the transfection of H19 siRNA in MSC. (d) RNA level of miR-139 was promoted by the transfection of H19 siRNA in MSC. (e) mRNA level of CXCR4 was inhibited by the transfection of H19 siRNA in MSC. (f) Protein level of ICAM-1 was reduced with the presence of H19 siRNA in MSC. (g) Protein level of CXCR4 was reduced with the presence of H19 siRNA in MSC.

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