H19 Overexpression Improved Efficacy of Mesenchymal Stem Cells in Ulcerative Colitis by Modulating the miR-141/ICAM-1 and miR-139/CXCR4 Axes

Figure 5

Effects of DSS, MSC, and MSC-H19 on mice weight and colon length. (a) Body weight loss of mice was highest in the DSS group, while MSC treated and MSC-H19 treated both obstructed this negative effect (). (b) Colon length of mice was shortest in the DSS group and longest in the SHAM group ( value <0.05 vs. control; value <0.05 vs. DSS; # value <0.05 vs. DDS + MSC). (c) Histological inflammatory score of HE staining of mice was the highest in the DSS group and lowest in the SHAM group ( value <0.05 vs. control; value <0.05 vs. DSS; # value <0.05 vs. DDS + MSC). (d) CRP level of mice was the highest in the DSS group and lowest in the SHAM group ( value <0.05 vs. control; value <0.05 vs. DSS; # value <0.05 vs. DDS + MSC).

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