Research Article
Plasma S-Adenosylmethionine Is Associated with Lung Injury in COVID-19
Table 1
Comparative characteristics of patients with different severities of coronavirus infection.
| | Mild | Moderate+severe | |
| | 34 | 22 | | Age, y | 62 [50.8; 67.8] | 57.5 [50.5; 64.0] | 0.775 | , | 7 | 5 | | Sex, man (%) | 24 (71) | 19 (86) | 0.171 | Lung CT: | | | | 0,1 | 19 | 7 | 0.078 | 2 | 10 | 6 | 0.865 | 3 | 5 | 7 | 0.129 | 4 | 0 | 2 | 0.073 | Alcohol consumption | 3 | 1 | 0.545 | Chronic cardiovascular diseases | 9 | 7 | 0.667 | Heart failure | 8 | 5 | 0.944 | Diabetes mellitus | 3 | 1 | 0.549 | Cancer | 5 | 2 | 0.535 | Chronic kidney disease | 3 | 0 | 0.153 | Chronic obstructive lung disease | 2 | 0 | 0.246 | Comorbidities (3 and more) | 8 | 4 | 0.631 | HCT, % | 41 [33; 44] | 43 [42; 45] | 0.011 | LI | 2.15 [1.53; 3.3] | 4.05 [2.55; 5.7] | 0.005 | GSH, μM | 1.74 [1.07; 2.32] | 0.99 [0.68; 1.40] | 0.011 | Hcy, μM | 7.9 [6.3; 9.3] | 7.3 [6.0; 11.9] | 0.987 | SAM, nM | 61 [50; 79] | 75 [52; 115] | 0.164 | SAH, nM | 13.6 [10.5; 21.6] | 14.0 [9.9; 19.5] | 0.973 | SAM/SAH | 4.5 [3.0; 7.2] | 6.0 [3.6; 8.6] | 0.196 | SAM/GSH, nM/μM | 37.8 [28.8; 63.2] | 60.6 [41.7; 254] | 0.016 |
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CT: computed tomography; GSH: glutathione; HCT: hematocrit; Hcy: homocysteine; LI: leukocyte index; SAH: S-adenosylhomocysteine; SAM: S-adenosylmethionine.
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