Plasma S-Adenosylmethionine Is Associated with Lung Injury in COVID-19

Table 1

Comparative characteristics of patients with different severities of coronavirus infection.

	Mild	Moderate+severe
	34	22
Age, y	62 [50.8; 67.8]	57.5 [50.5; 64.0]	0.775
,	7	5
Sex, man (%)	24 (71)	19 (86)	0.171
Lung CT:
0,1	19	7	0.078
2	10	6	0.865
3	5	7	0.129
4	0	2	0.073
Alcohol consumption	3	1	0.545
Chronic cardiovascular diseases	9	7	0.667
Heart failure	8	5	0.944
Diabetes mellitus	3	1	0.549
Cancer	5	2	0.535
Chronic kidney disease	3	0	0.153
Chronic obstructive lung disease	2	0	0.246
Comorbidities (3 and more)	8	4	0.631
HCT, %	41 [33; 44]	43 [42; 45]	0.011
LI	2.15 [1.53; 3.3]	4.05 [2.55; 5.7]	0.005
GSH, μM	1.74 [1.07; 2.32]	0.99 [0.68; 1.40]	0.011
Hcy, μM	7.9 [6.3; 9.3]	7.3 [6.0; 11.9]	0.987
SAM, nM	61 [50; 79]	75 [52; 115]	0.164
SAH, nM	13.6 [10.5; 21.6]	14.0 [9.9; 19.5]	0.973
SAM/SAH	4.5 [3.0; 7.2]	6.0 [3.6; 8.6]	0.196
SAM/GSH, nM/μM	37.8 [28.8; 63.2]	60.6 [41.7; 254]	0.016

CT: computed tomography; GSH: glutathione; HCT: hematocrit; Hcy: homocysteine; LI: leukocyte index; SAH: S-adenosylhomocysteine; SAM: S-adenosylmethionine.