Histone Deacetylase Inhibitors: A Promising Therapeutic Alternative for Endometrial Carcinoma

Table 3

Antitumor effects of HDACIs on human EC cells in mouse models.

HDACI	Upregulatory effects	Downregulatory effects	Synergetic effects	References
Apicidin	n/a	HDAC3, HDAC4, PCNA, VEGF, Tumor growth	n/a	[37]
TSA	n/a	n/a	Paclitaxel: reduction in tumor weight, increase in microtubule stabilization, apoptosis induction, tubulin acetylation induction	[50]
SAHA	n/a	n/a	Caspase-8 inhibition: tumor growth inhibition	[53]
NaB	n/a	SA-β-gal activity, Tumor growth	n/a	[65]
VPA	CDH1 mRNA	Bcl-2, Tumor growth	n/a	[41, 56, 79]
MHY2256	n/a	Tumor growth	n/a	[41, 79]
OBP-801/YM753	n/a	n/a	LY294002: tumor growth inhibition	[72]