Review Article
FGF23: A Review of Its Role in Mineral Metabolism and Renal and Cardiovascular Disease
Table 1
Hypophosphatemic diseases caused by FGF23 overproduction and hyperactivity.
| Disease | Cause |
| Autosomal dominant hypophosphatemic rickets/osteomalacia | Dysregulated expression of FGF23 by mutations in the FGF23 gene | Autosomal recessive hypophosphatemic rickets/osteomalacia | Overexpression of FGF23 in bone by mutation in the DMP1 gene | X-linked hypophosphatemic rickets/osteomalacia | Overexpression of FGF23 in bone by mutation in the PEHX gene | McCune-Albright syndrome/fibrous dysplasia | Overexpression of FGF23 in bone | Tumor-induced rickets/osteomalacia | Overexpression of FGF23 in responsible tumors |
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