PFKFB4 Overexpression Facilitates Proliferation by Promoting the G1/S Transition and Is Associated with a Poor Prognosis in Triple-Negative Breast Cancer

Table 1

Associations between the PFKFB4 expression and clinicopathologic factors of 180 patients with triple-negative breast cancer.

Characteristics	PFKFB4 expression (cases)		value
	Low	High
Total	132	48
Age (years)
≤30	6 (4.5%)	1 (2.1%)	0.450
>30	126 (95.5%)	47 (97.9%)
Family history of cancer			0.761
No	122 (92.4%)	45 (93.8%)
Yes	10 (7.6%)	3 (6.3%)
Menopause			0.289
No	68 (51.5%)	29 (60.4%)
Yes	64 (48.5%)	19 (39.6%)
History of other neoplasms			0.907
No	127 (86.2%)	46 (95.8%)
Yes	5 (3.8%)	2 (4.2%)
Stage			0.537
0/I/II	89 (66.7%)	30 (74.7%)
III	43 (33.3%)	18 (25.3%)
T status			0.163
Tis/T1/T2	111 (84.1%)	36 (75.0%)
T3/T4	21 (15.9%)	12 (25%)
Lymph node metastasis			0.636
N0	63 (47.7%)	21 (43.8%)
N1-3	69 (52.3%)	27 (56.2%)
Vascular invasion
No	107 (81.1%)	34 (70.8%)	0.141
Yes	25 (18.9%)	14 (29.2%)
Disease recurrence
No	89 (67.4%)	17 (35.4%)	0.000
Yes	43 (32.6%)	31 (64.6%)
Death
No	95 (72.0%)	18 (37.5%)	0.000
Yes	37 (28.0%)	30 (62.5%)