PFKFB4 Overexpression Facilitates Proliferation by Promoting the G1/S Transition and Is Associated with a Poor Prognosis in Triple-Negative Breast Cancer

Table 2

Univariate and multivariate analyses of the overall survival of the 180 TNBC patients. Stage III disease, lymph node metastasis, and high PFKFB4 expression were independent risk factors for a reduced OS rate (HR: hazard ratio; CI: confidence interval).

Variables	Overall survival
	Univariate analysis		Multivariate analysis
	HR (95% CI)	value	HR (95% CI)	value
	0.877 (0.275-2.797)	0.824
Family history of cancer	1.714 (0.781-3.762)	0.179
Menstruating	1.280 (0.787-2.083)	0.320
History of other neoplasms	1.384 (0.433-4.419)	0.584
Stage III disease	4.400 (2.675-7.238)	0.000	2.739 (1.444-5.195)	0.008
T3/T4	3.138 (1.889-5.215)	0.000	1.320 (0.685-2.543)	0.407
Lymph node metastasis	3.714 (2.088-6.606)	0.000	2.336 (1.207-4.520)	0.012
Vascular invasion	3.107 (1.891-5.104)	0.000	1.351 (0.742-2.459)	0.325
High PFKFB4 expression	3.148 (1.928-5.139)	0.000	4.061 (2.424-6.831)	0.000