PFKFB4 Overexpression Facilitates Proliferation by Promoting the G1/S Transition and Is Associated with a Poor Prognosis in Triple-Negative Breast Cancer

Table 3

Univariate and multivariate analyses of the disease-free survival of the 180 TNBC patients. Stage III disease, lymph node metastasis, and high PFKFB4 expression were independent risk factors for a reduced DFS rate (HR: hazard ratio; CI: confidence interval).

Variables	Disease-free survival
	Univariate analysis		Multivariate analysis
	HR (95% CI)	value	HR (95% CI)	value
	0.916 (0.288-2.912)	0.881
Family history of cancer	1.491 (0.683-3.259)	0.316
Menstruating	1.409 (0.883-2.248)	0.151
History of other neoplasms	1.264 (0.397-4.022)	0.691
Stage III disease	4.112 (2.575-6.566)	0.000	2.494 (1.376-4.520)	0.003
T3/T4	3.037 (1.860-4.959)	0.000	1.443 (0.768-2.710)	0.255
Lymph node metastasis	3.426 (2.011-5.837)	0.000	2.266 (1.239-4.143)	0.008
Vascular invasion	2.983 (1.639-5.429)	0.000	1.433 (0.811-2.531)	0.215
High PFKFB4 expression	2.712 (1.697-4.333)	0.000	3.439 (2.111-5.601)	0.000