Pentraxin 3 and the TyG Index as Two Novel Markers to Diagnose NAFLD in Children

Table 3

Comparison of the predictive value for diagnosing NAFLD between PTX-3, the TyG index, or ALT and their combination.

	Cut-off value	Sensitivity (95% CI)	Specificity (95% CI)	AUC (95% CI)	PPV (%)	NPV (%)
ALT	20 U/l	75 (62.6-85.0)	89.06 (78.8-95.5)	0.873 (0.802-0.925)	0.75	0.89
PTX-3	1.89 ng/ml	65.62 (52.7-77.1)	71.87 (59.2-82.4)	0.731 (0.646-0.806)	0.66	0.72
TyG	8.16	81.25 (69.5-89.9)	60.94 (47.9-72.9)	0.765 (0.682-0.835)	0.81	0.61
Combined model		90.62 (80.7-96.5)	95.31 (86.9-99.0)	0.964 (0.916-0.989)	0.91	0.95

Note: , compared with the AUC of ALT, ; , compared with the AUC of ALT, . AUC: the area under the ROC curve; PPV: positive predictive value; NPV: negative predictive value.