Prognostic Value of Pretreated Blood Inflammatory Markers in Patients with Bone Sarcoma: A Meta-Analysis

Table 2

Subgroup analysis of the prognostic value of NLR for OS.

Subgroup analysis	No. of studies	(%)	HR	95% CI
OS; Total	9	78.2	1.76	1.29-2.41	<0.001
Histology type
Osteosarcoma	6	85.4	1.78	1.18-2.69	0.006
Ewing sarcoma	2	0	2.11	1.26-3.54	0.005
Chondrosarcoma	1	-	1.17	0.69-2.01	0.557
Mixed	1	-	2.2	0.96-5.02	0.061
Ethnicity
Asian	7	83.1	1.66	1.17-2.36	0.005
Non-Asian	2	0	2.25	1.34-3.77	0.002
Analysis method
MA	7^+	81	1.7	1.16-2.49	0.006
UA	3	0	1.76	1.29-2.41	<0.001
Metastasis status
With metastatic cases	8	79.6	1.73	1.25-2.4	0.001
Without metastatic cases	1	-	2.2	0.96-5.02	0.061

Vasquez et al. study reported Ewing sarcoma cohort and osteosarcoma cohort separately. +: Vasquez et al. study reported NLR of Ewing sarcoma cohort by means of MA and osteosarcoma cohort with UA. Abbreviations: NLR: neutrophil lymphocyte ratio; HR: hazard ratio; CI: confidence interval; MA: multivariate analysis; UA: univariate analysis.