A 5-lncRNA Signature Associated with Smoking Predicts the Overall Survival of Patients with Muscle-Invasive Bladder Cancer
Table 4
Univariate and multivariate Cox regression analyses of five-lncRNA signature in prediction of overall survival.
Variable
Univariate analysis
Multivariate analysis
HR
95% CI
value
HR
95% CI
value
Risk score (high vs. low)
2.720
1.659–4.460
<0.001
2.210
0.845–2.430
<0.001
Age
1.027
1.008–1.047
<0.006
1.032
1.009–1.054
0.005
Gender
0.971
0.622–1.514
0.895
Tumor subtype
1.916
1.182–3.105
0.008
1.503
0.872–2.591
0.208
T stage (T2 vs. T3-4)
1.996
1.227–3.247
0.005
1.433
0.845–2.430
0.182
N stargea
2.185
1.461–3.270
<0.001
1.848
1.212–2.819
0.004
Pathological stage (II-III vs. IV)
2.051
1.393–3.201
<0.001
1.848
1.212–2.819
0.004b
Histological grade
3.130
0.770–12.723
0.111
Family history
0.868
0.579–1.301
0.493
Smoking statusa
1.428
0.903–2.258
0.128
aBinary variables: no lymph node involvement versus otherwise; nonmetastasis versus otherwise; nonsmoker and smoker for ≤15 years versus smoker for >15 years. bConstant or linear covariance makes N stage = pathological stage. HR: hazard ratio; CI: confidential interval; vs.: versus. Statistically significant results (in bold).
