A 5-lncRNA Signature Associated with Smoking Predicts the Overall Survival of Patients with Muscle-Invasive Bladder Cancer

Table 5

Univariate and multivariate Cox regression analyses of the 5-lncRNA signature in the prediction of RSF.

Variable	Univariate analysis			Multivariate analysis
	HR	95% CI	value	HR	95% CI	value
Risk score (high vs. low)	3.008	1.652–5.476	<0.001	2.637	1.428–4.869	0.002
Age	1.098	0.659–1.831	0.720	1.386	0.761–2.524	0.286
Gender	1.051	0.588–1.881	0.867
Tumor subtype	1.916	1.182–3.105	0.016
T stage (T2 vs. T3-4)	2.627	1.319–5.234	0.006	2.024	0.923–4.436	0.078
N stage^a	2.346	1.380–3.990	<0.002	1.914	1.085–3.378	0.025
Pathological stage (II-III vs. IV)	2.051	2.233–3.695	<0.002	1.914	1.085–3.378	0.025^b
Histological grade	5.396	0.743–38.816	0.096
Family history	1.136	0.684–1.886	0.622
Smoking status^a	0.805	0.453–1.432	0.460

^aBinary variables: no lymph node involvement versus otherwise; nonsmoker and smoker for ≤15 years versus smoker for >15 years. ^bConstant or linear covariance makes N stage = pathological stage. HR: hazard ratio; CI: confidential interval; vs.: versus. Statistical significant results (in bold).