Expression of Glutamine Metabolism-Related and Amino Acid Transporter Proteins in Adrenal Cortical Neoplasms and Pheochromocytomas

<div>Correlation between the expression levels of glutamine metabolism-related and amino acid transporter proteins and clinicopathologic factors. In adrenal cortical neoplasms, GLS positivity was associated with a higher Fuhrman grade, and SLC1A5 positivity was associated with SDHB positivity and a clear cell <span class="nowrap"><svg height="11.5564pt" id="M49" style="vertical-align:-3.16842pt" version="1.1" viewbox="-0.0498162 -8.38798 94.8813 11.5564" width="94.8813pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M169 380V459C122 440 66 423 24 416V392C86 384 90 382 90 317V-135C90 -201 81 -207 17 -213V-240H253V-213C176 -207 169 -201 169 -125V6C182 -1 208 -11 238 -12C368 12 487 109 487 260C487 358 421 449 310 449C298 449 279 444 261 433L169 380ZM169 346C196 367 237 389 269 389C341 389 403 329 403 221C403 109 347 37 263 37C228 37 191 53 169 76V346Z"></path></g><g transform="matrix(.013,0,0,-0.013,6.655,0)"><path d="M181 342V451C133 431 89 419 40 411V388C98 381 102 377 102 311V104C102 38 95 32 33 26V0H263V26C186 32 181 38 181 104V287C203 343 235 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associated with tumor cell necrosis. In pheochromocytomas, SLC7A11 positivity was associated with nonnorepinephrine types of tumors.</div>

Disease Markers

fig3

Figure 3

Figure 3: Expression of Glutamine Metabolism-Related and Amino Acid Transporter Proteins in Adrenal Cortical Neoplasms and Pheochromocytomas 