Homocysteine Level and Risk of Hemorrhage in Brain Arteriovenous Malformations

Table 3

Logistic regression analysis on the risk of hemorrhage.

Variables	Univariate analysis			Multivariate analysis
	OR	95% CI	value	OR	95% CI	value
Age	0.985	0.962-1.009	0.220	0.980	0.954-1.007	0.154
Male sex	1.135	0.587-2.196	0.707	1.565	0.686-3.568	0.287
Medical history
Hypertension	3.500	0.701-17.467	0.127
Diabetes mellitus	1.889	0.167-21.311	0.607
Cigarette smoking	1.108	0.473-2.598	0.813	0.974	0.325-2.914	0.962
Alcohol drinking	1.226	0.430-3.495	0.703
Prior treatments
Embolization	2.067	0.780-5.475	0.144	2.848	0.868-9.347	0.084
Radiosurgery	4.928	0.561-43.286	0.150
Microsurgery	1.415	0.229-8.737	0.708
AVM characteristics
Maximum diameter	0.668	0.519-0.859	0.002	0.634	0.479-0.839	0.001
Deep location	1.012	0.465-2.205	0.976	1.271	0.507-3.187	0.609
Eloquent location	1.087	0.564-2.094	0.804	1.230	0.561-2.698	0.605
Deep venous drainage	0.967	0.473-1.977	0.927	0.914	0.391-2.135	0.836
Associated aneurysms	1.030	0.408-2.603	0.950	1.184	0.415-3.380	0.753
Clinical features
Heart rate	1.014	0.981-1.049	0.402
SBP	1.000	0.978-1.022	>0.999
DBP	1.013	0.981-1.046	0.432
BMI	0.937	0.867-1.013	0.102
Laboratory results
Glucose	1.510	0.965-2.362	0.071
Albumin	0.976	0.886-1.074	0.614
Creatinine	0.978	0.957-1.000	0.051
UA	1.000	0.999-1.001	0.964
TC	0.912	0.638-1.305	0.616
TG	1.052	0.764-1.449	0.756
HDL-C	1.819	0.851-3.886	0.123
LDL-C	0.724	0.493-1.064	0.100
ApoA	0.916	0.272-3.089	0.888
ApoB	0.404	0.081-2.012	0.269
Hcy	0.965	0.934-0.998	0.038	0.956	0.920-0.993	0.021

OR: odds ratio; CI: confidence intervals; AVM: arteriovenous malformation; SBP: systolic blood pressure; DBP: diastolic blood pressure; BMI: body mass index; UA: uric acid; TC: total cholesterol; TG: triglyceride; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; ApoA: apolipoprotein A; ApoB: apolipoprotein B; Hcy: homocysteine. , significant difference.