The Diagnostic Value of Serum PIVKA-II Alone or in Combination with AFP in Chinese Hepatocellular Carcinoma Patients

Table 3

Diagnostic accuracy of the AFP and PIVKA-II in early stage HCC.

	Se (%)	Sp (%)	PPV (%)	NPV (%)	Accuracy (%)	AUC (95% CI)	Kappa
HCC vs. all controls
AFP	60.9	89.2	83.8	71.3	75.6	0.75 (0.68-0.81)	0.50
PIVKA-II	74.5	91.7	89.1	79.7	89.8	0.83 (0.77-0.89)	0.67
-II	83.3	89.1	89.3	83.1	86.1	0.86 (0.81-0.91)	0.72
HCC vs. LC
AFP	60.9	83.3	87.0	53.8	68.8	0.72 (0.64-0.80)	0.39
PIVKA-II	74.5	90.0	93.2	65.9	80.0	0.82 (0.75-0.88)	0.60
AFP + PIVKA-II	83.3	76.7	87.7	69.7	81.2	0.82 (0.74-0.89)	0.59

Se: sensitivity; Sp: specificity; PPV: positive predictive value; NPV: negative predictive value; AUC: area under the curve; CI: confidence interval; AFP: alpha-fetoprotein; PIVKA-II: prothrombin induced by vitamin K absence II; LC: HBV-related liver cirrhosis.