The Diagnostic Value of Serum PIVKA-II Alone or in Combination with AFP in Chinese Hepatocellular Carcinoma Patients

Table 4

Correlation between serum PIVKA-II level and clinical characteristics of HCC.

Characteristic		PIVKA- (mAU/ml)	PIVKA- (mAU/ml)	value
Age (years)				0.002
≤50	136	5	131
>50	172	25	147
Sex				0.056
Male	271	22	249
Female	37	8	29
Tumor size (cm)				<0.001
≤3	70	24	46
3~5	43	2	41
5~10	92	4	88
>10	103	0	103
Tumor number				0.010
Single	206	28	178
Multiple	102	2	100
Lymphatic metastasis				< 0.001
No	285	30	225
Yes	23	0	23
Distant metastasis				0.377
No	293	30	263
Yes	15	0	15
BCLC stage				<0.001
0	26	9	17
A	84	17	67
B	164	4	160
C	34	0	34
Tumor differentiation				0.027
Well-differentiated	22	9	13
Moderately/poorly differentiated	158	26	94
Microvascular invasion				0.576
No	120	9	111
Yes	60	6	54
PVTT				0.010
No	243	30	213
Yes	65	0	65

N: number of patients; AFP: alpha-fetoprotein; PIVKA-II: prothrombin induced by vitamin K absence II; PVTT: portal vein tumor thrombus; significant difference ().