Systemic Coagulation Markers Especially Fibrinogen Are Closely Associated with the Aggressiveness of Prostate Cancer in Patients Who Underwent Transrectal Ultrasound-Guided Prostate Biopsy
Table 1
Baseline characteristics of the study subjects according to the risk of PCa.
All subjects ()
Low-intermediate risk ()
High risk ()
value
Demographic characteristics
Age (years)
0.129
BMI (kg/m2)
0.816
Hypertension ( (%))
157 (37.1)
24 (38.1)
133 (36.9)
0.888
Diabetes mellitus ( (%))
57 (13.5)
9 (14.3)
48 (13.3)
0.842
Coronary artery disease ( (%))
61 (14.4)
6 (9.5)
55 (15.3)
0.330
Clinicopathological characteristics
PSA (ng/mL)
<0.001
Stage
<0.001
T1
18 (4.3)
13 (20.6)
5 (1.4)
T2
225 (53.2)
50 (79.4)
175 (48.6)
T3
114 (27.0)
0
114 (31.7)
T4
66 (15.6)
0
66 (18.3)
ISUP grade ( (%))
<0.001
1
51 (12.1)
31 (49.2)
20 (5.6)
2
41 (9.7)
11 (17.5)
30 (8.3)
3
56 (13.2)
21 (33.3)
35 (9.7)
4
101 (23.9)
0
101 (28.1)
5
174 (41.1)
0
174 (48.3)
Coagulation parameters
Fibrinogen (g/L)
<0.001
D-dimer (ng/mL)
320 (168-589)
223 (145-320)
360 (180-654)
<0.001
PT (s)
0.043
PT (%)
0.018
INR
0.002
APTT (s)
0.209
APTT ratio
0.875
TT (s)
0.961
TT ratio
0.092
AT-III (%)
0.248
Data are expressed as (%), , or median (interquartile range). The bold value indicated statistical significance. PCa = prostate cancer; BMI = body mass index; PSA = prostate-specific antigen; ISUP = International Society of Urological Pathology; PT = prothrombin; INR = international normalized ratio; APTT = activated partial thromboplastin time; TT = thrombin time; AT-III = antithrombin-III.
