Systemic Coagulation Markers Especially Fibrinogen Are Closely Associated with the Aggressiveness of Prostate Cancer in Patients Who Underwent Transrectal Ultrasound-Guided Prostate Biopsy
Table 2
Clinical characteristics of study subjects according to tertiles of plasma fibrinogen levels.
Fibrinogen tertiles
value
T1 (<2.74 g/L, )
T2 (2.75-3.41 g/L, )
T3 (>3.41 g/L, )
Age (years)
0.957
PSA (ng/mL)
<0.001
Stage
0.001
T1
9 (6.4)
4 (2.8)
5 (3.6)
T2
84 (59.6)
84 (59.2)
57 (40.7)
T3
36 (25.5)
35 (24.6)
43 (30.7)
T4
12 (8.5)
19 (13.4)
35 (25.0)
N
N0
114 (80.9)
100 (70.4)
71 (50.7)
<0.001
N1
27 (19.1)
42 (29.6)
69 (49.3)
M
<0.001
M0
98 (69.5)
90 (63.4)
51 (36.4)
M1
43 (30.5)
52 (36.6)
89 (63.6)
ISUP grade ( (%))
0.045
1
22 (15.6)
15 (10.6)
14 (10.0)
2
17 (12.1)
13 (9.2)
11 (7.9)
3
24 (17.0)
16 (11.3)
16 (11.4)
4
36 (25.5)
38 (26.8)
27 (19.3)
5
42 (29.8)
60 (42.3)
72 (51.4)
Coagulation parameters
D-dimer (ng/mL)
231 (143-400)
293 (162-470)
520 (285-1050)
<0.001
PT (s)
<0.001
PT (%)
0.007
INR
<0.001
APTT (s)
0.948
APTT ratio
0.174
TT (s)
<0.001
TT ratio
<0.001
AT-III (%)
<0.001
Data are expressed as (%), , or median (interquartile range). The bold value indicated statistical significance. PSA = prostate-specific antigen; ISUP = International Society of Urological Pathology; PT = prothrombin; INR = international normalized ratio; APTT = activated partial thromboplastin time; TT = thrombin time; AT-III = antithrombin-III.
