Systemic Coagulation Markers Especially Fibrinogen Are Closely Associated with the Aggressiveness of Prostate Cancer in Patients Who Underwent Transrectal Ultrasound-Guided Prostate Biopsy
Table 3
Univariate and multivariate analyses to reveal the correlation between coagulation parameters and high risk of PCa.
Univariate mode
Multivariate mode
OR (95% CI)
value
OR (95% CI)
value
Fibrinogen (g/L)
2.041 (1.376-3.027)
<0.001
2.169 (0.716-6.570)
0.171
T1 (<2.74 g/L)
Reference
Reference
Reference
Reference
T2 (2.75-3.41 g/L)
1.537 (0.840-2.814)
0.163
0.748 (0.158-3.550)
0.715
T3 (>3.41 g/L)
3.664 (1.719-7.808)
0.001
15.202 (1.725-133.959)
0.014
D-dimer (ng/mL)
1.003 (1.002-1.005)
<0.001
1.001 (0.998-1.004)
0.448
T1 (<211 ng/mL)
Reference
Reference
Reference
Reference
T2 (212-469 ng/mL)
1.268 (0.692-2.321)
0.442
0.313 (0.070-1.394)
0.127
T3 (>469 ng/mL)
3.507 (1.385-8.875)
0.008
3.139 (0.310-31.779)
0.333
PT (s)
1.247 (1.006-1.546)
0.044
0.695 (0.379-1.273)
0.239
PT (%)
0.989 (0.981-0.998)
0.019
1.000 (0.977-1.024)
0.981
INR
50.64 (2.67-957.84)
0.009
0.072 (0.000-257.72)
0.529
T1 (<9.9 s)
Reference
Reference
Reference
Reference
T2 (10.0-11.4 s)
1.873 (0.991-3.542)
0.053
2.059 (0.458-9.256)
0.346
T3 (>11.4 s)
2.124 (1.086-4.154)
0.028
0.476 (0.079-2.876)
0.419
APTT (s)
0.964 (0.911-1.021)
0.209
APTT ratio
0.855 (0.121-6.032)
0.875
TT (s)
0.997 (0.890-1.118)
0.962
TT ratio
0.090 (0.006-1.377)
0.084
AT-III (%)
0.990 (0.971-1.010)
0.342
Logistic regression analyses were performed. The multivariate model was adjusted for PSA, ISUP grade, and stage. The bold value indicated statistical significance. PCa = prostate cancer; PT = prothrombin; INR = international normalized ratio; APTT = activated partial thromboplastin time; TT = thrombin time; AT-III = antithrombin-III.
