Disease Markers

Research Article

Clinicopathological, Radiological, and Molecular Features of Primary Lung Adenocarcinoma with Morule-Like Components

Table 1

Clinicopathologic characteristics of lung adenocarcinomas with MLCs.


Case no.	Age (years)/sex/smoking	Location	Size (cm)	Histologic findings					Treatment	TNM stage	Follow-up (months)
Case no.	Age (years)/sex/smoking	Location	Size (cm)	Proportion of MLCs (%)	Predominant component	Other components	STAS	Visceral pleural invasion	Treatment	TNM stage	Follow-up (months)

1	50/F/no	LLL	2.2	10	Acinar	Micropapillary	—	—	Lobectomy	T1N1M0	AWT (45)
2	46/F/no	RLL	2.5	15	Acinar	Micropapillary	+	—	Lobectomy	T1N0M0	NET (38)
3	68/F/no	LUL	3.0	20	Acinar	Micropapillary	—	+	Lobectomy	T2N0M0	NET (37)
4	46/F/no	RUL	2.5	5	Acinar	Lepidic/micropapillary	—	—	Lobectomy	T1N0M0	NET (37)
5	48/M/yes	LUL	2.0	5	Lepidic	Acinar	+	—	Lobectomy	T1N1M0	NET (34)
6	66/M/yes	LLL	3.2	15	Lepidic	Papillary/cribriform	—	—	Lobectomy	T2N1M0	DOT(22)
7	55/F/no	RLL	3.1	10	Lepidic	Papillary	—	—	Lobectomy	T2N0M0	NET (33)
8	51/M/no	RLL	1.2	15	Lepidic	Acinar	—	—	Lobectomy	T1N1M0	NET (32)
9	56/F/no	LUL	1.0	20	Papillary	Lepidic	—	—	Lobectomy	T1N0M0	NET (32)
10	53/M/yes	LLL	2.0	15	Lepidic	Cribriform	—	+	Lobectomy	T2N1M0	DOT (3)
11	68/F/no	LUL	2.5	25	Lepidic	Acinar	—	—	Lobectomy	T1N0M0	NET (30)
12	60/M/no	LLL	2.0	5	Lepidic	Acinar/micropapillary	—	—	Wedge resection	T1N0M0	NET (30)
13	56/M/yes	LLL	3.4	15	Lepidic	Papillary/micropapillary/acinar	+	+	Lobectomy	T2N1M0	NET (29)
14	68/F/yes	RML	1.3	5	Lepidic	Cribriform/micropapillary	+	—	Lobectomy	T1N0M0	NET (28)
15	55/F/no	LUL	2.5	35	Acinar	Micropapillary	+	—	Lobectomy	T1N0M0	Lost to follow-up
16	70/F/no	RUL	2.3	50	Acinar	None	—	+	Wedge resection	T2N0M0	NET (28)
17	61/M/no	RUL	3.0	10	Acinar	Micropapillary	—	—	Lobectomy	T1N1M0	NET (27)
18	48/F/no	LUL	2.8	5	Lepidic	Acinar	—	+	Lobectomy	T2N0M0	NET (27)
19	66/F/yes	LUL	2.5	10	Acinar	Lepidic	—	+	Lobectomy	T2N0M0	NET (27)
20	68/F/no	RLL	1.7	5	Papillary	Lepidic	—	—	Lobectomy	T1N0M0	NET (26)

AWT: alive with tumor (recurrence); DOT: died of tumor; F: female; LLL: left lower lobe; LUL: left upper lobe; M: male; NET: no evidence of tumor; RLL: right lower lobe; RML: right middle lobe; RUL: right upper lobe; STAS: spread through air spaces. This case was a minimally invasive adenocarcinoma.