Association between Plasma Homocysteine Concentrations and the First Ischemic Stroke in Hypertensive Patients with Obstructive Sleep Apnea: A 7-Year Retrospective Cohort Study from China

Table 2

Association between Hcy and incident of the first IS in different models.

Exposure	Crude model (HR to 95% CI to )	Adjust model I (HR to 95% CI to )	Adjust model II (HR to 95% CI to )	Adjust model III (HR to 95% CI to )
Continuous
Hcy (per SD increment)	1.37 (1.30 to 1.44) <0.01	1.35 (1.27 to 1.42) <0.01	1.34 (1.26 to 1.43) <0.01	1.32 (1.24 to 1.38) <0.01
Categorical
Hcy tertiles (μmol/L)
Tertile 1 (<11.6)	Reference	Reference	Reference	Reference
Tertile 2 (11.6–18.2)	2.91 (2.42 to 3.49) <0.01	2.67 (2.22 to 3.20) <0.01	2.33 (1.94 to 2.72) <0.01	2.13 (1.74 to 2.59) <0.01
Tertile 3 (>18.2)	2.75 (2.29 to 3.31) <0.01	2.23 (1.85 to 2.70) <0.01	1.96 (1.73 to 2.19) <0.01	1.76 (1.43 to 2.17) <0.01

Crude model: adjusted for none. Adjust model I: adjusted for age and gender at baseline. Adjust model II: adjusted for variables in adjusted model I plus smoking status, drinking status, NC, WC, and BMI at baseline. Adjust model III: fully adjusted model. Adjusted for variables in adjusted model II plus SBP, DBP, history of arrhythmia and diabetes, AHI, AI, HI, sleep duration, mean SaO₂ and lowest SaO₂, antidiabetic drugs, antiplatelet drugs, lipid-lowering drugs, regular CPAP treatment, antihypertensive drugs, and TC, TG, HDL-c, LDL-c, FPG, eGFR, Cr, and hs-CRP levels at baseline. Abbreviations are the same as in Table 1.