Jiangzhi Ligan Decoction Inhibits GSDMD-Mediated Canonical/Noncanonical Pyroptosis Pathways and Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease

Figure 2

Effects of JZLGD on liver histology and hepatic inflammation-related parameters in HFD-fed NAFLD rats. (a) H&E staining (200x magnification) showed that inflammatory cell infiltration, balloon-like degeneration, and liver steatosis were obvious in the HFD group and inhibited in the JZLGD-treated NAFLD groups. Immediately afterwards, the NAFLD activity score (b) and (c) ballooning pathology score were recorded to evaluate the lesions better. (d–g) IL-1β, IL-18, TNF-α, and IL-6 serum levels were analyzed by ELISA. Data are expressed as the (); vs. control; ^#, ^## vs. HFD group.

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