Reproduction of the Cancer Genome Atlas (TCGA) and Asian Cancer Research Group (ACRG) Gastric Cancer Molecular Classifications and Their Association with Clinicopathological Characteristics and Overall Survival in Moroccan Patients
Table 1
Clinicopathological features related to the TCGA subtypes.
Variable
(%)
EBV+ ()
MSI ()
GS ()
CIN ()
value
Gender
0.094
-Male
59 (60.8%)
6 (100)
7 (53.8)
16 (57.1)
30 (60)
-Female
38 (39.2%)
0 (0)
6 (46.2)
12 (42.9)
20 (40)
Mean age at diagnosis (range)
59 (28-85)
61 (46-77)
59 (36-85)
56 (28-76)
62 (39-82)
0.275
Age at diagnosis
0.424
-≥50 years
80 (82.5)
5 (83.3)
9 (69.2)
22 (78.6)
44 (88)
-<50 years
17 (17.5)
1 (16.7)
4 (30.8)
6 (21.4)
6 (12)
History of gastrectomy
0.374
-Yes
7 (7.2)
1 (16.7)
0 (0)
3 (10.7)
3 (6)
-No
90 (92.8)
5 (83.3)
13 (100)
25 (89.3)
47 (94)
History of gastric ulcer
0.025
-Yes
3 (3.1)
2 (33.3)
0 (0)
0 (0)
1 (2)
-No
94 (96.9)
4 (66.7)
13 (100)
28 (100)
49 (98)
Tobacco smoking
0.161
-Yes
25 (25.8)
3 (50)
1 (7.7)
6 (21.4)
15 (30)
-No
72 (74.2)
3 (50)
12 (92.3)
22 (78.6)
35 (70)
Tumor location
0.789
-Cardia
31 (31.9)
2 (33.3)
4 (30.8)
11 (39.3)
14 (28)
-Noncardia
66 (68.1)
4 (66.7)
9 (69.2)
17 (60.7)
36 (72)
Tumor cells differentiation
0.081
-Well/moderate
62 (63.9)
2 (33.3)
7 (53.8)
15 (53.6)
38 (76)
-Poor
35 (36.1)
4 (66.7)
6 (46.2)
13 (46.4)
12 (24)
Lauren classification
0.001
-Intestinal
65 (67.1)
3 (50)
11 (84.6)
11 (39.3)
40 (80)
-Diffuse/mixed
32 (32.9)
3 (50)
2 (15.4)
17 (60.7)
10 (20)
HER2 immunostaining
0.906
-Positive
9 (9.3)
1 (16.7)
1 (7.7)
2 (7.1)
5 (10)
-Negative
88 (90.7)
5 (83.3)
12 (92.3)
26 (92.9)
45 (90)
p53 immunostaining
0.134
-Aberrant
49 (50.5)
2 (33.3)
5 (38.5)
11 (39.3)
31 (62)
-Normal
48 (49.5)
4 (66.7)
8 (61.5)
17 (60.7)
19 (38)
PD-L1 immunostaining
0.177
-Positive
6 (15.8)
1 (33.3)
3 (50)
0 (0)
2 (10.5)
-Negative
32 (84.2)
2 (66.7)
3 (50)
10 (100)
17 (89.5)
TCGA: The Cancer Genome Atlas; EBV: Epstein-Barr virus; MSI: microsatellite instability; GS: genome stable; CIN: chromosomal instability; previously reported [13].
