Reproduction of the Cancer Genome Atlas (TCGA) and Asian Cancer Research Group (ACRG) Gastric Cancer Molecular Classifications and Their Association with Clinicopathological Characteristics and Overall Survival in Moroccan Patients

Table 3

Clinicopathological features related to the integrated classification subtypes.

Variable	(%)	EBV+ ()	MSI ()	E-cadherin aberrant ()	p53 aberrant ()	p53 normal ()	value
Gender							0.168
-Male	59 (60.8%)	6 (100)	7 (53.8)	16 (57.1)	19 (61.3)	11 (57.9)
-Female	38 (39.2%)	0 (0)	6 (46.2)	12 (42.9)	12 (38.7)	8 (42.1)
Mean age at diagnosis (range)	59 (28-85)	61 (46-77)	59 (36-85)	56 (28-76)	60 (39-80)	65 (39-82)	0.218
Age at diagnosis							0.581
-≥50 years	80 (82.5)	5 (83.3)	9 (69.2)	22 (78.6)	27 (87.1)	17 (89.5)
-<50 years	17 (17.5)	1 (16.7)	4 (30.8)	6 (21.4)	4 (12.9)	2 (10.5)
History of gastrectomy							0.055
-Yes	7 (7.2)	1 (16.7)	0 (0)	3 (10.7)	0 (0)	3 (15.8)
-No	90 (92.8)	5 (83.3)	13 (100)	25 (89.3)	31 (100)	16 (84.2)
History of gastric ulcer							0.023
-Yes	3 (3.1)	2 (33.3)	0 (0)	0 (0)	0 (0)	1 (5.3)
-No	94 (96.9)	4 (66.7)	13 (100)	28 (0)	31 (100)	18 (94.7)
Tobacco smoking							0.252
-Yes	25 (25.8)	3 (50)	1 (7.7)	6 (21.4)	10 (32.3)	5 (26.3)
-No	72 (74.2)	3 (50)	12 (92.3)	22 (78.6)	21 (67.7)	14 (73.7)
Tumor location							0.186
-Cardia	31 (31.9)	2 (33.3)	4 (30.8)	11 (39.3)	12 (38.7)	2 (10.5)
-Noncardia	66 (68.1)	4 (66.7)	9 (69.2)	17 (60.7)	19 (61.3)	17 (89.5)
Tumor cells differentiation							0.051
-Well/moderate	62 (63.9)	2 (33.3)	7 (53.8)	15 (53.6)	26 (83.9)	12 (63.2)
-Poor	35 (36.1)	4 (66.7)	6 (46.2)	13 (46.4)	5 (16.1)	7 (36.8)
Lauren classification							0.002
-Intestinal	65 (67.1)	3 (50)	11 (84.6)	11 (39.3)	26 (83.9)	14 (73.7)
-Diffuse/mixed	32 (32.9)	3 (50)	2 (15.4)	17 (60.7)	5 (16.1)	5 (26.3)
HER2 immunostaining							0.789
-Positive	9 (9.3)	1 (16.7)	1 (7.7)	2 (7.1)	2 (6.5)	3 (15.8)
-Negative	88 (90.7)	5 (83.3)	12 (92.3)	26 (92.9)	29 (93.5)	16 (84.2)
PD-L1 immunostaining							0.324
-Positive	6 (15.8)	1 (33.3)	3 (50)	0 (0)	1 (9.1)	1 (12.5)
-Negative	32 (84.2)	2 (66.7)	3 (50)	10 (100)	10 (90.9)	7 (87.5)

EBV: Epstein-Barr virus; MSI: microsatellite instability; previously reported [13].