A Systematic Review of Clinical Validated and Potential miRNA Markers Related to the Efficacy of Fluoropyrimidine Drugs

<div>Metabolic pathway map of 5-FU. Abbreviations: 5-FU: 5-Fluorouracil; CES1: recombinant carboxylesterase 1; UPP1: uridine phosphorylase 1; 5<span class="nowrap"><svg height="7.86364pt" id="M2" style="vertical-align:-0.04981995pt" version="1.1" viewbox="-0.0498162 -7.81382 4.53621 7.86364" width="4.53621pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M295 534L291 558C277 573 202 603 180 597L75 72L120 51L295 534Z"></path></g></svg>-</span>dFCR: 5<span class="nowrap"><svg height="7.86364pt" id="M3" style="vertical-align:-0.04981995pt" version="1.1" viewbox="-0.0498162 -7.81382 4.53621 7.86364" width="4.53621pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M295 534L291 558C277 573 202 603 180 597L75 72L120 51L295 534Z"></path></g></svg>-</span>deoxy-5-fluorocytidine; CDA: cytidine deaminase; TYMP: thymidine phosphorylase; DPYS: dihydropyrimidinase; FUPA: 5-fluorouracil-hydantoic-acid; UPB1: recombinant beta-ureidopropionase; TK1: thymidine kinase 1; UMPS: uridine monophosphate synthetase; PPAT: phosphoribosyl pyrophosphate amido transferase; DHFU: dihydrofluorouracil; FUR: fluorouridine; FUMP: fluorouridine monophosphate; FUDP: fluorouridine diphospho; FUTP: fluorouridine triphosphate; FdUDP: fluorodeoxyuridine diphospho; FdUMP: fluorodeoxyuridine monophosphate; FdUTP: fluorodeoxyuridine triphosphate; dUMP: deoxy-uridine monophosphate; and dTMP: deoxy-thymidine monophosphate.</div>

Disease Markers

fig2

Figure 2

Figure 2: A Systematic Review of Clinical Validated and Potential miRNA Markers Related to the Efficacy of Fluoropyrimidine Drugs 