Review Article

A Systematic Review of Clinical Validated and Potential miRNA Markers Related to the Efficacy of Fluoropyrimidine Drugs

Table 2

The list of miRNAs affecting the expression of 5-FU metabolic enzymes.

Affected proteinMicroRNARelated cancer (cell lines or patients)

ABCC5(+)miR-101 [74]HCC
ABCC1(+)miR-199 [74]HCC
ABCC1(-)miR-326 [75]Breast cancer
ABCC2(-)miR-397 [76]Hepatoblastoma cell
ABCC3(-), ABCC6(-)miR-9 [77]Glioma cell
ABCC4(-)miR-125 [74]Hepatocellular carcinoma
ABCG2(-)miR-212 [78]Myelogenous leukemia
ABCG2(-)miR-328 [7881]Breast cancer, retinoblastoma, myelogenous leukemia, and CRC
ABCG2(-)miR-519 [79, 82, 83]Colon cancer, breast cancer, and retinoblastoma
DPYD(-)miR-134 [84]HCC, lung cancer
DPYD(-)miR-494 [85]Colon cancer
DPYD(-)miR-582 [84]HCC
DPYD(-), P-gp(-)miR-302 [86, 87]HCC and breast cancer
P-gp(-)miR-103 [88]Gastric cancer
P-gp(-)miR-107 [88]Gastric cancer
P-gp(-)miR-129 [89]Gastric cancer
P-gp(+)miR-130 [90]Ovarian cancer
P-gp(-)miR-137 [91]Breast cancer
P-gp(-)miR-138 [92]Leukemia
P-gp(-)miR-298 [93]Breast cancer
P-gp(-)miR-30 [94]Gastric cancer
P-gp(-)miR-331 [95]Chronic myelogenous leukemia
P-gp(-), ABCB1(-)miR-451[9698]Breast cancer, CRC
P-gp(-)miR-506 [99]CRC
P-gp(-), ABCG2(-)miR-145 [100, 101]Colon carcinoma
P-gp(-), ABCG2(-), ABCG5(-)miR-200 [102, 103]Breast cancer and melanomas
TP(-), DPYD(-)miR-21 [30]CRC
TS(-)miR-192 [104]CRC
TS(-)miR-196 [37]Rectal cancer
TS(-)miR-197 [105]CRC
TS(-)miR-203 [106]CRC
TS(-)miR-215 [37, 104, 107110]CRC, soft tissue sarcoma, renal cancer, and head and neck cancer
P-gp(+)miR-218 [38]CRC
TS(-)miR-24 [107]Soft tissue sarcoma
TS(-)miR-433 [111]HCC
TS(-)miR-450 [37]Rectal cancer
TS(-)miR-99 [37]Rectal cancer
ABCC5(-)TS(-)Let-7e [37, 74]Rectal cancer, HCC
TS(-), ABCC3(-)miR-192 [104, 112]CRC and esophageal adenocarcinoma
TS(-), ABCC3(-)miR-193 [112]Esophageal adenocarcinoma
TS(-), ABCC3(-)miR-378 [112]Esophageal adenocarcinoma
TS(-), ABCG2(-)miR-520 [80, 113115]HCC, pancreatic cancer, and retinoblastoma
TS(-), DPYD(-), P-gp(-), ABCC3(-)miR-27 [37, 38, 74, 93, 95, 96, 102, 105, 116, 117]CRC, HCC, lung cancer, gastric cancer, breast cancer, esophageal adenocarcinoma, leukemia, and ovarian cancer

The effect of miRNAs on each enzyme’s expression was noted as “+” for inducing and “-” for suppressing. Abbreviations: CRC: colorectal cancer; HCC: hepatocellular carcinoma.