A Systematic Review of Clinical Validated and Potential miRNA Markers Related to the Efficacy of Fluoropyrimidine Drugs
Table 4
Top 20 significant KEGG pathways enriched by fluoropyrimidine drug efficacy–related miRNAs in CRC cohorts with/without metastasis.
Without metastasis
With metastasis
KEGG pathway
Genes
Ratio (%)
value
KEGG pathway
Genes
Ratio (%)
value
MicroRNAs in cancer
62
20.00
9.87E-11
Chronic myeloid leukemia
22
28.95
6.36E-09
FoxO signaling pathway
36
27.48
7.13E-10
Cellular senescence
30
18.75
2.46E-07
Cellular senescence
40
25.00
1.21E-09
TGF-beta signaling pathway
22
23.40
5.48E-07
MAPK signaling pathway
57
19.39
3.38E-09
FoxO signaling pathway
26
19.85
8.85E-07
Autophagy
33
24.09
2.47E-07
Non-small cell lung cancer
18
27.27
1.09E-06
Proteoglycans in cancer
42
20.49
3.02E-07
MicroRNAs in cancer
43
13.87
1.31E-06
PI3K-Akt signaling pathway
60
16.95
3.1E-07
Pancreatic cancer
19
25.00
1.99E-06
Hepatitis B
36
22.22
4.58E-07
Signaling pathways regulating pluripotency of stem cells
26
18.18
5.82E-06
AGE-RAGE signaling pathway in diabetic complications
26
26.00
2.53E-06
Pathways in cancer
59
11.11
1.22E-05
Pancreatic cancer
22
28.95
3.94E-06
Proteoglycans in cancer
31
15.12
2.4E-05
Pathways in cancer
76
14.31
5.99E-06
Hepatocellular carcinoma
27
16.07
4.4E-05
Colorectal cancer
23
26.74
9.64E-06
Glioma
17
22.67
5.26E-05
Kaposi sarcoma-associated herpesvirus infection
37
19.58
9.82E-06
Hepatitis B
26
16.05
7.44E-05
Glioma
21
28.00
1.52E-05
Cell cycle
22
17.74
9.85E-05
Human cytomegalovirus infection
41
18.22
1.78E-05
Prostate cancer
19
19.59
0.000119
Chronic myeloid leukemia
21
27.63
1.94E-05
MAPK signaling pathway
37
12.59
0.000177
Bladder cancer
15
36.59
2.18E-05
Gastric cancer
24
16.11
0.000187
Prostate cancer
24
24.74
2.41E-05
AGE-RAGE signaling pathway in diabetic complications
19
19.00
0.00019
Genes related to miRNA from the two CRC cohorts were subjected to KEGG pathway enrichment analysis. The top 20 pathways with gene numbers higher than five and values less than 0.05 (corrected by the two-side Bonferroni test) were listed here.
