A Systematic Review of Clinical Validated and Potential miRNA Markers Related to the Efficacy of Fluoropyrimidine Drugs
Table 5
Top five significant gene ontology (GO) terms enriched by fluoropyrimidine drug efficacy related miRNAs in CRC cohorts with/without metastasis.
Without metastasis
With metastasis
GO term
Genes
Ratio (%)
value
GO term
Genes
Ratio (%)
value
CC
Intracellular organelle
791
6.01
2.60E-23
Intracellular organelle
1079
8.20
2.15E-29
CC
Nucleus
534
6.88
5.02E-21
Membrane-bounded organelle
1059
8.20
1.55E-27
CC
Membrane-bounded organelle
772
5.98
2.24E-20
Intracellular membrane-bounded organelle
959
8.43
2.23E-25
CC
Intracellular membrane-bounded organelle
705
6.20
2.78E-20
Nucleoplasm
444
10.63
4.40E-23
CC
Nucleoplasm
333
7.97
4.07E-19
Nuclear lumen
505
10.16
7.21E-23
MF
Enzyme binding
219
9.23
5.89E-18
Enzyme binding
278
11.72
6.49E-18
MF
Regulatory region nucleic acid binding
113
10.82
2.79E-12
Phosphotransferase activity, alcohol group as acceptor
192
13.41
2.22E-17
MF
Sequence-specific DNA binding
136
9.79
8.82E-12
Transferase activity, transferring phosphorus-containing groups
218
12.20
3.41E-15
MF
Transcription regulatory region sequence-specific DNA binding
112
10.74
9.23E-12
Regulatory region nucleic acid binding
148
14.18
6.59E-15
MF
Sequence-specific double-stranded DNA binding
114
10.45
2.42E-11
Transcription regulatory region sequence-specific DNA binding
147
14.09
1.88E-14
BP
Regulation of cellular metabolic process
510
7.77
6.99E-34
G1/S transition of mitotic cell cycle
52
19.48
9.10E-09
B.P.
Regulation of primary metabolic process
484
7.62
1.38E-28
Negative regulation of transcription by RNA polymerase II
132
14.12
7.85E-13
B.P.
Regulation of nitrogen compound metabolic process
473
7.68
1.55E-28
Mitotic cell cycle
146
13.21
7.20E-12
B.P.
Regulation of metabolic process
532
7.29
4.96E-28
Cell morphogenesis
135
11.93
1.70E-07
B.P.
Regulation of macromolecule metabolic process
496
7.38
4.72E-26
Cell morphogenesis involved in differentiation
96
11.82
1.77E-04
Genes related to miRNA from the two CRC cohorts were subjected to G.O. enrichment analysis. The top G.O. terms with gene numbers higher than five and values less than 0.05 (corrected by the two-side Bonferroni test) were listed here. Three ontology sources were analyzed in this step: cellular component (CC), molecular function (M.F.), and biological process (B.P.).
