Apolipoprotein E ε4 Polymorphism as a Risk Factor for Ischemic Stroke: A Systematic Review and Meta-Analysis

Table 2

The main results of the APOE gene associated with IS included in the meta-analysis.

Genetic model of APOE gene polymorphisms	Group	No. of included studies	Results of association with IS
			OR	95% CI	value of ORs
ε2 allele vs. ε3 allele	All	51	0.983	(0.867,1.115)	0.79
	LAA	13	0.962	(0.712,1.299)	0.80
	CE	10	1.517	(0.861,2.674)	0.15
	SAD	12	1.190	(0.997,1.421)	0.05
ε4 allele vs. ε3 allele	All	51	1.374	(1.214,1.556)	<0.0001
	LAA	13	1.149	(0.898,1.469)	0.27
	CE	10	1.092	(0.662,1.801)	0.73
	SAD	12	1.318	(1.073,1.618)	0.01
ε2/ε2 vs. ε3/3	All	36	0.985	(0.653,1.486)	0.94
	LAA	11	1.307	(0.750,2.278)	0.35
	CE	10	4.290	(1.917,9.600)	<0.0001
	SAD	11	1.803	(1.037,3.134)	0.04
ε2/ε3 vs. ε3/3	All	46	0.980	(0.900,1.066)	0.63
	LAA	13	0.869	(0.705,1.071)	0.19
	CE	10	1.255	(0.849,1.856)	0.26
	SAD	12	1.178	(0.952,1.457)	0.13
ε2/ε4 vs. ε3/3	All	42	1.233	(1.056,1.440)	0.01
	LAA	11	0.978	(0.607,1.576)	0.93
	CE	10	1.458	(0.534,3.980)	0.46
	SAD	10	0.932	(0.526,1.652)	0.81
ε3/ε4 vs. ε3/3	All	47	1.340	(1.165,1.542)	<0.0001
	LAA	14	1.154	(0.841,1.584)	0.38
	CE	10	1.175	(0.627,2.203)	0.62
	SAD	13	1.392	(1.097,1.767)	0.01
ε4/ε4 vs. ε3/3	All	46	1.833	(1.542,2.179)	<0.0001
	LAA	13	1.367	(0.836,2.236)	0.21
	CE	10	1.543	(0.591,4.029)	0.38
	SAD	11	1.809	(1.030,3.175)	0.04
ε4 vs. non-ε4	All	50	1.377	(1.203,1.576)	<0.0001
	LAA	14	1.149	(0.876,1.506)	0.32
	CE	10	1.091	(0.645,1.845)	0.74
	SAD	13	1.329	(1.064,1.661)	0.01
ε2 vs. non-ε2	All	48	0.956	(0.841,1.086)	0.49
	LAA	14	0.861	(0.717,1.035)	0.11
	CE	10	1.358	(0.966,1.910)	0.08
	SAD	13	1.117	(0.926,1.347)	0.25
ε4/ε4 vs. ε2/4	All	40	1.625	(1.281,2.060)	<0.0001
	LAA	11	1.551	(0.791,3.043)	0.20
	CE	9	0.771	(0.177,3.352)	0.73
	SAD	4	2.115	(0.919,4.867)	0.08
ε4/ε4 vs. ε3/4	All	46	1.301	(1.077,1.571)	0.01
	LAA	13	1.353	(0.811,2.258)	0.25
	CE	6	1.077	(0.402,2.887)	0.88
	SAD	11	1.332	(0.739,2.400)	0.34