Siglec-15 Silencing Inhibits Cell Proliferation and Promotes Cell Apoptosis by Inhibiting STAT1/STAT3 Signaling in Anaplastic Thyroid Carcinoma

Figure 3

Identification of overall survival-related immune-related genes and construction of the prognostic model. (a) Forest plots of the 23 OS-related hub TCIGs identified by Cox proportional hazard regression. The represented prognostic hub TCIGs with hazard ratios >1 are shown as red dots, and the represented prognostic hub TCIGs with hazard ratios <1 are shown as green dots. (b) Risk score distribution of THCA patients. (c) Survival status of THCA patients with increasing risk score. (d) Heat map of 15 hub TCIGs by definite multivariate Cox regression analysis in the high-risk group and low-risk group. (e) The Kaplan-Meier survival curve analysis for the high- and low-risk group based on the risk score. (f) ROC curve for predicting prognosis gene performance based on risk score. (g) Univariate and (h) multivariate Cox regression analyses of the risk score. (i) Heat map showing the distribution of clinical features between the high- and low-risk groups. The risk scores in different (j) age, (k) gender, and (l) stage for THCA patients. .

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