Urinary PCA3 a Superior Diagnostic Biomarker for Prostate Cancer among Ghanaian Men

Table 3

Diagnostic performance of total serum PSA, PCA3 score, and DRE.

Variable	Sensitivity (95% CI)	Specificity (95% CI)	PPV (%)	NPV (%)	TP	TN	FP	FN
PSA (ng/ml)	92.1 (82.2–96.9)	16.1 (11.4–22.4)	28.4	84.8	58	28	146	5
PCA3 score	57.1 (44.9–68.6)	85.6 (79.6–90.1)	59.0	84.7	36	149	25	27
DRE	93.7 (84.2–97.9)	12.1 (8.0–17.8)	27.7	84.0	59	21	153	4

PSA: prostate-specific antigen; PCA3: prostate cancer antigen 3; DRE: digital rectal examination; CI: confidence interval; PPV: positive predictive value; NPV: negative predictive value; TP: true positive; TN: true negative; FP: false positive; FN: false negative.